DNA Methylation data from frozen placental tissue



Maternal obesity alters placental tissue function and morphology with a corresponding increase in local inflammation.; We and others showed that placenta size, inflammation and fetal growth are regulated by maternal diet and obesity status. Maternal obesity alters placental DNA methylation which in turn could likely impact gene transcription of; of proteins critical for normal fetal development. RNA-binding motif single-stranded interacting protein 1 (RBMS1) is expressed by the placenta and likely modulates DNA replication and transcription regulation.; Serum RBMS1 protein concentration is increased with maternal obesity and RBMS1 gene expression in liver tissue is induced by a high-fat diet and inflammation. However, it is not yet known whether placental RBMS1 mRNA expression and DNA methylation are altered by maternal obesity.

Overall Design

Methylation profiles of frozen placental tissue samples from overweight/obese (BMI>25) and non-overweight (BMI<25) were anaylzed


Data and Resources

Raw Files [38]

Additional Info

Field Value
Source https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE120062
Type of Data

Methylation profiling by genome tiling array


Methylation Array

GSE Submission Date 17/09/2018
GSE Authors Kate,,Claycombe; Archana Dhasarathy; Amy,N,Bundy; Atrayee Bhattacharya; Diane Darland; Junguk Hur; Danielle Perley; LuAnn Johnson; James,N,Roemmich
Dataset Last Updated December 1, 2020, 21:34 (UTC)
Dataset Created December 1, 2020, 17:09 (UTC)