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DNA modification study in major depressive disorder

gse37579

Description

Major depressive disorder (MDD) exhibits numerous clinical, epidemiological, and molecular features that are consistent with partially inherited and partially acquired epigenetic misregulation. We performed microarray based DNA modification study of MDD, utilizing affected and unaffected samples from white blood cells from monozygotic twins discordant for MDD, post-mortem prefrontal cortex tissues, and sperm samples.

Overall Design

We performed DNA methylome analysis on white blood cells from monozygotic twins discordant for depression (n=200), pre-frontal cortex (n=71), and germline samples (n=33) from affected individuals and controls (total n=304). DNA samples were enriched for unmodified fraction of the genome using DNA-modification sensitive restriction enzyme digestion followed by adaptor-mediated PCR. The enriched fractions were labelled with a fluorescent dye (Cy5) and hybridized onto the array with a common reference pool (Cy3) generated from individuals unrelated to this study.

Histogram

Data and Resources

Raw Files [304]

Additional Info

Field Value
Source https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE37579
Type of Data

Methylation profiling by genome tiling array

Technology

Methylation Array

GSE Submission Date 25/04/2012
GSE Authors Gabriel,,Oh; Sun-Chong Wang; ZhengFei Chen; Tarang Khare; Mamoru Tochigi; Catherine Ng; Angela Yang; Mrinal Pal; Andrew Kwan; Zachary Kaminsky; Jonathan Mill; Andrew Heath; Pamela Madden; Cerisse Gunasinghe; Jennifer Tackett; Irving Gottesman; Gustavo Tur
Dataset Last Updated November 29, 2019, 14:19 (UTC)
Dataset Created November 29, 2019, 13:01 (UTC)