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Hypermethylation in the ZBTB20 gene is associated with major depressive disorder

gse54222

Description

Genome-wide MeDIP-Sequencing was carried out on a total of 50 monozygotic twin pairs from the UK and Australia that are discordant for depression. We show that major depressive disorder is associated with significant hypermethylation within the coding region of ZBTB20, and is replicated in an independent cohort of 356 unrelated case-control individuals. The twins with major depressive disorder also show increased global variation in methylation in comparison with their unaffected co-twins. ZBTB20 plays an essential role in the specification of the Cornu Ammonis-1 field identity in the developing hippocampus, a region previously implicated in the development of major depressive disorder.

Overall Design

Epigenetic study of MZ twins discordant for Major Depressive Disorder

Histogram

Data and Resources

Raw Files [54]

Additional Info

Field Value
Source https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE54222
Type of Data

Methylation profiling by high throughput sequencing

Technology

Methylation Sequencing

GSE Submission Date 20/01/2014
GSE Authors Jordana,T,Bell; Matthew,N,Davies
Dataset Last Updated November 29, 2019, 16:27 (UTC)
Dataset Created November 29, 2019, 13:01 (UTC)