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Expression data from human brain orbital ventral prefrontal cortex - including control samples and samples with major depression disorders (24 samples NY_BA47)

gse54575

Description

Major depressive disorder is a heterogeneous illness with a mostly uncharacterized pathology. Large scale gene expression (transcriptome) analysis and genome-wide association studies (GWAS) for single nucleotide polymorphisms have generated a considerable amount of gene- and disease-related information, but heterogeneity and various sources of noise have limited the discovery of disease mechanisms. As systematic dataset integration is becoming essential, we developed methods and performed meta-clustering of gene coexpression links in 11 transcriptome studies from postmortem brains of human subjects with major depressive disorder (MDD) and non-psychiatric control subjects. We next sought enrichment in the top 50 meta-analyzed coexpression modules for genes otherwise identified by GWAS for various sets of disorders. One coexpression module of 88 genes was consistently and significantly associated with GWAS for MDD, other neuropsychiatric disorders and brain functions, and for medical illnesses with elevated clinical risk of depression, but not for other diseases (See publication for details).

Overall Design

24 total samples in 12 pairs were analyzed in postmortem tissue from the orbital ventral prefrontal cortex.

Histogram

Data and Resources

Raw Files [24]

Additional Info

Field Value
Source https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE54575
Type of Data

Expression profiling by array

Technology

Microarray

GSE Submission Date 30/01/2014
GSE Authors Etienne,,Sibille
Pubmed ID 24608543
Dataset Last Updated November 29, 2019, 13:26 (UTC)
Dataset Created November 29, 2019, 13:01 (UTC)