Sexually dimorphic methylation of CD3+ T-lymphocyte DNA in offspring of overweight and obese mothers in a high risk, minority population in the Bronx



Maternal obesity impacts the health of offspring, increasing the risk of developing obesity and/or other metabolic dysregulation in childhood or later in life. Using a genome-wide methylation assay, we identified sex-dependent dysregulation of the methylome of CD3+ T-lymphocytes, a cell type that plays an important role in obesity and inflammatory diseases, in newborn offspring of overweight and obese mothers. Furthermore, the differentially methylated loci were targeted to regulatory regions of the genome, in imprinted genes and genes identified from GWAS as being related to type 2 diabetes and obesity.

Overall Design

DNA methylation was assessed globally at specific CpG sites in CD3+ T cell from 76 consenting women who delivered healthy, non-anomalous singleton AGA term neonates following an uncomplicated intrapartum course at the Weiler Division of Montefiore Medical Center.


Data and Resources

Raw Files [76]

Additional Info

Field Value
Type of Data

Methylation profiling by high throughput sequencing


Methylation Sequencing

GSE Submission Date 09/02/2017
GSE Authors Maureen,J,Charron; Yoshinori Seki; Lyda Williams; Mamta Fuloria; Masako Suzuki
Dataset Last Updated December 1, 2020, 21:35 (UTC)
Dataset Created December 1, 2020, 17:09 (UTC)