Datasets
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[gse39445] Effect of sleep restriction on the human transcriptome during exte...
Number of resources: 427 (427 raw, 0 normalizations, 0 DE files)In a cross balanced design human subjects were given one week of sufficient sleep and insufficient sleep (6 h per day). Following each of these conditions they were then kept... -
[gse45642] Circadian patterns of gene expression in the human brain and disru...
Number of resources: 670 (670 raw, 0 normalizations, 0 DE files)A cardinal symptom of Major Depressive Disorder (MDD) is the disruption of circadian patterns. Yet, to date, there is no direct evidence of circadian clock dysregulation in the... -
[gse98564] Gene expression biomarkers for neurobehavioral impairment from tot...
Number of resources: 199 (199 raw, 0 normalizations, 0 DE files)Healthy human adults were recruited to a sleep lab at Washington State University and remained there 7 consecutive days. Six received a well-rested Control condition of 10 h... -
[gse109269] Bone marrow lympho-myeloid malfunction in obesity requires precur...
Number of resources: 11 (11 raw, 0 normalizations, 0 DE files)Obesity, a prevalent condition in adults and children, impairs bone marrow (BM) function. However, the underlying mechanisms are unclear. Here we show that obese mice exhibit... -
[gse94729] Sexually dimorphic methylation of CD3+ T-lymphocyte DNA in offspri...
Number of resources: 76 (76 raw, 0 normalizations, 0 DE files)Maternal obesity impacts the health of offspring, increasing the risk of developing obesity and/or other metabolic dysregulation in childhood or later in life. Using a... -
[gse69769] MeDIP and hMeDIP assays using human placentas of obese and lean (h...
Number of resources: 4 (4 raw, 0 normalizations, 0 DE files)Maternal obesity has both a direct effect on the outcome of pregnancy but also programs the fetus for obesity and metabolic syndrome in later life. Due to its roles at the... -
[gse120062] DNA Methylation data from frozen placental tissue
Number of resources: 38 (38 raw, 0 normalizations, 0 DE files)Maternal obesity alters placental tissue function and morphology with a corresponding increase in local inflammation.; We and others showed that placenta size, inflammation and... -
[gse97554] Primate fetal hepatic response to maternal obesity: epigenetic sig...
Number of resources: 11 (11 raw, 0 normalizations, 0 DE files)The liver is a major site for synthesis, storage and redistribution of carbohydrates, proteins and lipids. In addition, it is well-known that maternal obesity (MO) increases... -
[gse43685] Early growth response protein-1 coordinates lipotoxicity-associate...
Number of resources: 8 (8 raw, 0 normalizations, 0 DE files)Maternal obesity during pregnancy leads to a pro-inflammatory milieu in the placenta. We conducted a global transcriptomic profiling in BeWo cells following palmitic acid (PA,... -
[gse127711] Blood Biomarkers for Memory: Towards Early Detection of Risk for ...
Number of resources: 734 (734 raw, 0 normalizations, 0 DE files)Short-memory dysfunction is a key early feature of Alzheimer Disease. Psychiatric patients may be at higher risk for memory dysfunction and subsequent Alzheimer due to the... -
[gse89595] Signiture microRNA expression patterns identified in Williams synd...
Number of resources: 66 (66 raw, 0 normalizations, 0 DE files)Williams Syndrome (WS) is a rare neurodevelopmental disorder caused by heterozygous deletions in a chromosome 7q11.23 region typically encompassing 26-28 genes. WS patients... -
[gse87768] Circulating miRNA Associated with Posttraumatic Stress Disorder in...
Number of resources: 48 (48 raw, 0 normalizations, 0 DE files)Objective: Posttraumatic stress disorder (PTSD) affects a high proportion of returning combat veterans, but the biological mechanisms of PTSD remain unclear. Circulating micro... -
[gse71661] TTF1 and TKTL1 mRNAs in Extracellular Vesicles as a Blood Biomarke...
Number of resources: 57 (57 raw, 0 normalizations, 0 DE files)Lung cancer remains the greatest cause of cancer related deaths and Low Dosage Computerized Tomography (LDCT) has been shown to improve early detection of lung cancer and... -
[gse89594] Integrated network analysis reveals genotype-phenotype correlation...
Number of resources: 94 (94 raw, 0 normalizations, 0 DE files)Williams Syndrome (WS) is a rare neurodevelopmental disorder caused by heterozygous deletions in a chromosome 7q11.23 region typically encompassing 26-28 genes. WS patients... -
[gse109499] Gain-of-function mutations in the serotonin transporter cluster t...
Number of resources: 10 (10 raw, 0 normalizations, 0 DE files)The human serotonin transporter SERT catalyzes serotonin reuptake at the synapse to terminate neurotransmission, and is targeted by therapeutics treating depression and anxiety... -
[gse104376] HM450 analysis pregnancy anxiety
Number of resources: 45 (45 raw, 0 normalizations, 0 DE files)DNA methylation profiling of low versus high pregnancy anxiety (22 versus 23 cord blood samples, respectively) using the Illumina Infinium HM450 array -
[gse80261] DNA methylation signature of human fetal alcohol spectrum disorder
Number of resources: 216 (216 raw, 0 normalizations, 0 DE files)Prenatal alcohol exposure is the leading preventable cause of behavioural and cognitive deficits, which may affect between 2-5% of children in North America. While the... -
[gse78975] Longitudinal DNA Methylome analysis from saliva sample of adolesce...
Number of resources: 96 (96 raw, 0 normalizations, 0 DE files)A cohort of adolescents and young adults took part in this longitudinal 5-year follow-up study. We selected four groups of subjects from the same community sample carefully... -
[gse128840] Neuronal deletion of Gtf2i, associated with Williams syndrome, ca...
Number of resources: 6 (6 raw, 0 normalizations, 0 DE files)Williams syndrome (WS), caused by a heterozygous microdeletion in 7q11.23, is a neurodevelopmental disorder characterized by hypersociability and neurocognitive abnormalities.... -
[gse119995] Exposure-induced changes of plasma mRNA expression levels in pati...
Number of resources: 72 (72 raw, 0 normalizations, 0 DE files)Anxiety disorders including panic disorders with or without agoraphobia are the most prevalent mental disorders. Exposure is a core technique within the framework of cognitive... -
[gse94119] Gene expression and response to psychological therapy
Number of resources: 315 (315 raw, 0 normalizations, 0 DE files)This study represents the first investigation of genome-wide expression profiles with respect to psychological treatment outcome. Participants (n=102) with panic disorder or... -
[gse18212] THE EFFECTS OF ALCOHOLISM ON THE HUMAN BASOLATERAL AMYGDALA
Number of resources: 2 (2 raw, 0 normalizations, 0 DE files)Alcohol affects gene expression in several brain regions. The amygdala is a key structure in the brain’s emotional system and in recent years the crucial importance of the... -
[gse60190] Genetic Neuropathology of Obsessive Psychiatric Syndromes
Number of resources: 133 (133 raw, 0 normalizations, 0 DE files)Anorexia nervosa (AN), bulimia nervosa (BN), and obsessive-compulsive disorder (OCD) are complex psychiatric disorders with shared obsessive features, thought to arise from the... -
[gse54400] Transcriptome analysis of human umbilical cord fibroblasts from ba...
Number of resources: 47 (47 raw, 0 normalizations, 0 DE files)In pregnancies involving preeclampsia (PE), there is evidence that the fetal-placental unit is under oxidative stress. Here we examined primary cell lines generated from... -
[gse27272] Comprehensive Study of Tobacco Smoke-Related Transcriptome Alterat...
Number of resources: 183 (183 raw, 0 normalizations, 0 DE files)Maternal smoking has a severe negative effect on all stages of pregnancy that in consequence impairs fetal growth and development. Tobacco smoke-related defects are well... -
[gse84018] DNA methylation in CD34 positive cells derived from cord blood at ...
Number of resources: 18 (18 raw, 0 normalizations, 0 DE files)DNA methylation profiling of CD34 positive cells derived from cord blood at birth following prenatal stress -
[gse72354] DNA methylation signatures triggered by prenatal maternal stress e...
Number of resources: 34 (34 raw, 0 normalizations, 0 DE files)Background: Prenatal maternal stress (PNMS) predicts a wide variety of behavioral and physical outcomes in the offspring. Although epigenetic processes may be responsible for... -
[gse19738] Major Depressive Disorder blood gene expression
Number of resources: 132 (132 raw, 0 normalizations, 0 DE files)Background: Major Depressive Disorder (MDD) is a moderately heritable disorder with a high lifetime prevalence. At present, laboratory blood tests to support MDD diagnosis are... -
[gse98793] Gene expression analysis in whole blood samples obtained from dono...
Number of resources: 192 (192 raw, 0 normalizations, 0 DE files)This study investigated gene expression changes in whole blood samples obtained from donors diagnosed with major depressive disorder (MDD) compared to healthy controls.... -
[gse56931] Blood gene expression reveals reduced circadian rhythmicity in ind...
Number of resources: 249 (249 raw, 0 normalizations, 0 DE files)To address whether changes in gene expression in blood cells with sleep loss are different in individuals resistant and sensitive to sleep deprivation (SD).; Blood draws every... -
[gse37667] The peripheral genome-wide gene expression profiles in humans afte...
Number of resources: 27 (27 raw, 0 normalizations, 0 DE files)Although the specific functions of sleep have not been completely elucidated, the literature has suggested that sleep is essential for proper homeostasis. Sleep loss is... -
[gse82114] The human blood transcriptome following sleep extension and sleep ...
Number of resources: 49 (49 raw, 0 normalizations, 0 DE files)In a cross balanced design human subjects were given one week of sufficient sleep and insufficient sleep (6 h per day). Following each of these conditions they were then kept... -
[gse82113] Mistimed sleep disrupts circadian regulation of the human blood tr...
Number of resources: 23 (23 raw, 0 normalizations, 0 DE files)4 healthy volunteers without sleep disorders were resident in an environmental scheduling facility and participated in a forced-desynchrony protocol, in which the sleep-wake... -
[gse48113] Mistimed sleep disrupts circadian regulation of the human blood tr...
Number of resources: 287 (287 raw, 0 normalizations, 0 DE files)22 healthy volunteers without sleep disorders were resident in an environmental scheduling facility and participated in a forced-desynchrony protocol, in which the sleep-wake... -
[gse98566] Gene expression biomarkers for neurobehavioral impairment from tot...
Number of resources: 163 (163 raw, 0 normalizations, 0 DE files)Healthy human adults were recruited to a sleep lab at Washington State University and remained there 7 consecutive days. Six received a well-rested Control condition of 10 h... -
[gse98565] Gene expression biomarkers for neurobehavioral impairment from tot...
Number of resources: 193 (193 raw, 0 normalizations, 0 DE files)Healthy human adults were recruited to a sleep lab at Washington State University and remained there 7 consecutive days. Six received a well-rested Control condition of 10 h... -
[gse38206] Transcription profiling of major depression peripheral blood monon...
Number of resources: 36 (36 raw, 0 normalizations, 0 DE files)PBMCs from major depressive episode (MDE) subjects were obtained at two time points: during a severe episode of depression and eight week later after clinical remission. PBMCs... -
[gse113725] DNA methylation and inflammation marker profiles associated with ...
Number of resources: 194 (194 raw, 0 normalizations, 0 DE files)Depression is a common and disabling disorder, representing a major social and economic health issue. Moreover, depression is associated with the progression of diseases with an... -
[gse44132] Antenatal Blood DNA Methylation Profiles
Number of resources: 55 (55 raw, 0 normalizations, 0 DE files)DNA methylation profiles were generating using Illumina HM450 microarrays in a prospective sample blood from the prenatal period of pregnant mood disorder patients who would and... -
[gse42546] Whole transcriptome analysis of postmortem human hippocampus denta...
Number of resources: 79 (79 raw, 0 normalizations, 0 DE files)We investigated the transcriptome of dentate gyrus (DG) granule cells in postmortem hippocampus from 79 subjects with mental illness (schizophrenia, bipolar disorder, major... -
[gse45603] Gene Expression Profiles Predict Postpartum-onset Depression Pati...
Number of resources: 210 (210 raw, 0 normalizations, 0 DE files)To identify early predictive biomarkers for postpartum depression using peripheral blood gene expression profiles -
[gse54222] Hypermethylation in the ZBTB20 gene is associated with major depre...
Number of resources: 54 (54 raw, 0 normalizations, 0 DE files)Genome-wide MeDIP-Sequencing was carried out on a total of 50 monozygotic twin pairs from the UK and Australia that are discordant for depression. We show that major depressive... -
[gse12654] Gene expression from human prefrontal cortex (BA10)
Number of resources: 50 (50 raw, 0 normalizations, 0 DE files)We performed the oligonucleotide microarray analysis in bipolar disorder, major depression, schizophrenia, and control subjects using postmortem prefrontal cortices provided by... -
[gse81152] MicroRNAs as diagnostic biomarkers for major depression
Number of resources: 80 (80 raw, 0 normalizations, 0 DE files)Blood samples taken from healthy controls and patients with major depression were analyzed for differences in microRNA expression. Patients were treated with either... -
[gse58105] Prefrontal cortex microRNA expression profiling in major depression
Number of resources: 25 (25 raw, 0 normalizations, 0 DE files)To gain insight into the potential role of miRNA in major depressive disorder, in this study we assessed global expression of miRNAs in the ventrolateral prefrontal cortex (PFC)... -
[gse113798] m6A/m-Seq of human B-lymphocyte cell lines from healthy controls ...
Number of resources: 25 (25 raw, 0 normalizations, 0 DE files)N6-Methyladenosine (m6A) and N6,2′-O-dimethyladenosine (m6Am) are abundant mRNA modifications that regulate transcript processing and translation. The role of both, here termed... -
[gse76826] Blood transcriptomic markers in patients with late-onset major dep...
Number of resources: 32 (32 raw, 0 normalizations, 0 DE files)Search for the biomarkers of major depressive disorder (MDD) has facilitated from the genes expressed in the patient’s blood cells. Because the severity of depressive symptoms... -
[gse101521] Whole-transcriptome brain expression and exon-usage profiling in ...
Number of resources: 86 (86 raw, 0 normalizations, 0 DE files)Brain gene expression profiling studies of suicide and depression using oligonucleotide microarrays have often failed to distinguish these two phenotypes. Moreover, next... -
[gse87610] Gene expression of L3 and L5 pyramidal neurons in the DLPFC compar...
Number of resources: 286 (286 raw, 0 normalizations, 0 DE files)Impairments in certain cognitive processes (e.g., working memory) are typically most pronounced in schizophrenia (SZ), intermediate in bipolar disorder (BP) and least in major... -
[gse88890] Major depression MDD suicide brain study
Number of resources: 75 (75 raw, 0 normalizations, 0 DE files)Background: Major Depressive Disorder (MDD) represents a major social and economic health issue and constitutes a major risk factor for MDD suicide. The molecular pathology of...